Arthrosamid® is an innovative hydrogel treatment that delivers proven, long-lasting relief for knee osteoarthritis — with just one injection.
Arthrosamid® is backed by randomized trials and long-term studies showing significant, lasting pain relief from a single injection. Every figure below is drawn from the peer-reviewed studies cited further down this page.
Pain is measured on the WOMAC scale (0–100) — the standard tool in osteoarthritis research, where a drop of about 11 points or more is considered clinically meaningful. Here's what the strongest studies found.
In a randomized controlled trial — the gold standard of medical evidence — 239 patients received either a single Arthrosamid® injection or a standard hyaluronic-acid gel injection. Arthrosamid® reduced pain at least as much as the established treatment.
The takeaway: One Arthrosamid® injection matched—and numerically outperformed—the most common gel injection used for knee arthritis.
The biggest Arthrosamid® study yet followed 199 people with moderate-to-severe knee osteoarthritis for a year after a single injection. Pain improved by an average of 17 points, with matching gains in stiffness and day-to-day function.
The takeaway: In the largest group studied, a single injection delivered a clinically meaningful drop in pain that lasted the full year.
Patients from the randomized trial were tracked for three years. Their pain stayed significantly below where it started — a 13.1-point WOMAC reduction that held steady, all from one treatment, with no top-up injections.
The takeaway: Relief doesn't fade after a few months — it was still clearly measurable three years on.
This long-term study followed patients for a full five years after a single injection. Pain reduction was still significant at the five-year mark, with a strong safety record and no serious treatment-related side effects.
The takeaway: For many patients, one injection can mean years of meaningful pain relief — not months.
A 2026 systematic review in the journal Cartilage — conducted independently of the manufacturer — pooled the published research on injectable hydrogels for knee osteoarthritis. It concluded that polyacrylamide hydrogels like Arthrosamid® produce meaningful improvements in WOMAC pain scores.
The takeaway: Independent reviewers weighing all the evidence reach the same conclusion on pain relief.
Individual results vary. WOMAC pain is scored 0–100; a reduction of roughly 11 points or more is generally considered clinically meaningful. These studies describe outcomes across groups of patients and are not a promise of any individual result.
Arthrosamid® is an innovative non-biodegradable hydrogel composed of 2.5% cross-linked polyacrylamide and 97.5% water. It is the first and only approved injectable implant that permanently integrates with the knee's synovial tissue.
By integrating into the tissue lining of the knee joint, it helps reduce joint stiffness, relieve pain, improve knee function, and enhance overall quality of life — all with a single treatment.
Arthrosamid® is suitable, safe and effective for most patients with knee osteoarthritis, with Health Canada approval.
Unlike hyaluronic acid injections with limited effectiveness beyond six months, Arthrosamid® offers pain reduction maintained for years.
Arthrosamid® is a simple, one-step procedure performed in one day without the usual recovery processes associated with surgery.
As Arthrosamid® integrates into the tissue lining of the knee joint, it helps soften and increase the elasticity of the tissue. This results in clinically proven reductions in joint stiffness and pain, along with improved knee function.
Arthrosamid® is a permanent injectable hydrogel that delivers long-lasting pain relief without surgery. It has redefined treatment for knee osteoarthritis.
It's this unique characteristic that provides a significant reduction in your OA pain over a longer period, with one single treatment.
Integrates with synovial tissue to soften and increase elasticity, easing joint movement.
Clinical studies demonstrate significant and sustained pain reduction after just one injection.
A minimally invasive alternative that can postpone or eliminate the need for joint replacement surgery.
Enhances knee function and overall quality of life, helping you move freely and live fully.
Mark Webb, Orthopaedic Surgeon Consultant, shares his experience.
Why leading surgeons chose to offer this treatment to their patients.
An overview of the growing number of successful treatments worldwide.
Contact us today to arrange a consultation and find out if Arthrosamid® is right for you.